High-level publications on QGel MT 3D Matrix have shown successful growth and proliferation of a variety of cell types. More specific applications include analysis of stem cell proliferation, tumor cell migration and invasion, study of the angiogenesis process and in vivo wound repair. The list below outlines some of the key studies that have been done using QGel Technology:

Repair of bone defects using synthetic mimetics of collagenous extracellular matrices.
Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Müller R, Hubbell JA.
Nat Biotechnol. 2003 May;21(5):513-8. Epub 2003 Apr 21. PMID: 12704396 [PubMed - indexed for MEDLINE]

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics.
Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA.
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5413-8. Epub 2003 Apr 9PMID: 12686696 [PubMed - indexed for MEDLINE]

Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell-responsive PEG-hydrogel.
Kraehenbuehl TP, Zammaretti P, Van der Vlies AJ, Schoenmakers RG, Lutolf MP, Jaconi ME, Hubbell JA.
Biomaterials. 2008 Jun;29(18):2757-66. Epub 2008 Apr 7.PMID: 18396331 [PubMed - indexed for MEDLINE]

Engineering integrin signaling for promoting embryonic stem cell self-renewal in a precisely defined niche.
Lee ST, Yun JI, Jo YS, Mochizuki M, van der Vlies AJ, Kontos S, Ihm JE, Lim JM, Hubbell JA.
2010 Feb;31(6):1219-26. Epub 2009 Nov 18.PMID: 19926127 [PubMed - indexed for MEDLINE]

Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration.
Raeber GP, Lutolf MP, Hubbell JA. PMID: 15923238 [PubMed - indexed for MEDLINE]

Capturing complex 3D tissue physiology in vitro.
Griffith LG, Swartz MA.
Nat Rev Mol Cell Biol. 2006 Mar;7(3):211-24. Review.PMID: 16496023 [PubMed - indexed for MEDLINE]See p 214 under:Designer 3D gels: the frontier is moving mainstream

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.
Lutolf MP, Hubbell JA.
Nat Biotechnol. 2005 Jan;23(1):47-55. Review. PMID: 15637621 [PubMed - indexed for MEDLINE]